About Quatrefolic
Quatrefolic® is available in several formats to suit different product formulations and delivery systems. It is commonly supplied as a stable powder suitable for use in tablets, capsules, sachets, and functional foods. The ingredient can also be incorporated into liquid supplements and fortified beverages due to its improved stability compared with many traditional folate sources.
Quatrefolic® Pro is a specialised version designed for premium formulations, combining the active folate form with complementary nutrients to support advanced nutritional applications. These options allow manufacturers to develop a wide range of consumer health products while delivering a highly bioavailable and stable source of folate.
Quatrefolic - application areas
- Prenatal and Maternal Health
- Cardiovascular Health
- Cognitive and Neurological Support
- Fertility and Reproductive Health
- Medical Nutrition and Methylation Support
- General Wellness and Cellular Health
Clinical Research
Quatrefolic® is supported by a growing body of clinical and pharmacokinetic research evaluating the efficacy and bioavailability of active folate (L-5-methyltetrahydrofolate).
Quatrefolic® has been studied across several key health areas where folate plays a recognised physiological role. Clinical investigations have primarily focused on maternal health and pregnancy, demonstrating effective improvement of folate status in women before and during pregnancy. Additional studies have explored applications in fertility support, particularly in assisted reproductive technologies, as well as cardiovascular health through the management of homocysteine levels.
Research has also confirmed the superior bioavailability of Quatrefolic® compared with standard folic acid, as it provides folate in its biologically active form. This enables efficient absorption and utilisation, including in individuals with reduced capacity to convert folic acid into active folate.
View the Quatrefolic® Pro video.
About Gnosis by Lesaffre
Gnosis by Lesaffre believe that good health must evolve from being reactive to being pre-emptive. By harnessing the power of micro-organisms and learning from nature’s intelligence, they create proactive, sustainable solutions that help people live stronger, longer and happier lives.
As an integrated part of the Lesaffre family, they are experts in biotransformation, tapping into over 170 years of expertise in fermentation and biotechnological innovation.